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A Regeneration rune is a river rune in Dota 2 that gives a hero rapid health and mana restoration for a short time, until the effect is interrupted by taking damage or spending mana. It is used to recover after fights, stay in lane longer, or prepare for the next engagement without returning to base.
Because it can quickly refill resources, a Regeneration rune is especially valuable for mid laners and heroes that need to keep pressure on the map.
Related: Power rune, Bounty rune, Rune
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